Trisha Shetty (Editor)


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Species  Human
Entrez  59
Human  Mouse
Ensembl  ENSG00000107796

Aliases  ACTA2, AAT6, ACTSA, MYMY5, actin, alpha 2, smooth muscle, aorta
External IDs  MGI: 87909 HomoloGene: 133938 GeneCards: ACTA2

Alpha-actin-2 also known as actin, aortic smooth muscle or alpha smooth muscle actin (α-SMA, SMactin, alpha-SM-actin, ASMA) is a protein that in humans is encoded by the ACTA2 gene located on 10q22-q24.

Actin alpha 2, the human aortic smooth muscle actin gene, is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.

Alpha-smooth muscle actin (α-SMA) is commonly used as a marker of myofibroblast formation (Nagamoto et al., 2000).


ACTA2 Wikipedia