Entrez 55902 | Ensembl ENSG00000131069 | |
Aliases ACSS2, ACAS2, ACECS, ACS, ACSA, dJ1161H23.1, acyl-CoA synthetase short-chain family member 2 External IDs MGI: 1890410 HomoloGene: 6469 GeneCards: ACSS2 | ||
Acyl-coenzyme A synthetase short-chain family member 2 is an enzyme that in humans is encoded by the ACSS2 gene.
Confusingly, this is not the same as the enzyme called acetyl-CoA synthetase 2, abbreviated AceCS2, whose gene is called ACSS1.
Function
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Two transcript variants encoding different isoforms have been found for this gene.
References
ACSS2 Wikipedia(Text) CC BY-SA