Samiksha Jaiswal

ACOT8

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Species  Human
Entrez  10005
Human  Mouse
Ensembl  ENSG00000101473
ACOT8
Aliases  ACOT8, HNAACTE, PTE-1, PTE-2, PTE1, PTE2, hACTE-III, hTE, NAP1, acyl-CoA thioesterase 8
External IDs  MGI: 2158201 HomoloGene: 3991 GeneCards: ACOT8

Acyl-coenzyme A thioesterase 8 is an enzyme that in humans is encoded by the ACOT8 gene.

The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. Multiple transcript variants encoding several different isoforms have been found for this gene.

References

ACOT8 Wikipedia


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