Aliases ABHD6 Human Mouse Ensembl ENSG00000163686 | Species Human Entrez 57406 | |
External IDs MGI: 1913332 HomoloGene: 23246 GeneCards: ABHD6 | ||
alpha/beta-Hydrolase domain containing 6 (ABHD6), also known as monoacylglycerol lipase ABHD6 or 2-arachidonoylglycerol hydrolase is an enzyme that in humans is encoded by the ABHD6 gene.
Function
ABHD6 is a serine hydrolyzing enzyme that possesses typical α/β-hydrolase family domains. ABHD6 was first studied because of its over-expression in certain forms of tumours.
ABHD6 has been linked to regulation of the endocannabinoid system as it controls the accumulation of 2-arachidonoylglycerol (2-AG) at the cannabinoid receptors.
ABHD6 accounts for about 4% of 2-AG brain hydrolysis. Together, monoacylglycerol lipase (MAGL), ABHD12, and ABHD6 control 99% of 2-AG signalling in the brain.
References
ABHD6 Wikipedia(Text) CC BY-SA