Kalpana Kalpana (Editor)

ABHD6

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Aliases
  
ABHD6

Human
  
Ensembl
  
ENSG00000163686

Species
  
Entrez
  
57406

External IDs
  
MGI: 1913332 HomoloGene: 23246 GeneCards: ABHD6

alpha/beta-Hydrolase domain containing 6 (ABHD6), also known as monoacylglycerol lipase ABHD6 or 2-arachidonoylglycerol hydrolase is an enzyme that in humans is encoded by the ABHD6 gene.

Function

ABHD6 is a serine hydrolyzing enzyme that possesses typical α/β-hydrolase family domains. ABHD6 was first studied because of its over-expression in certain forms of tumours.

ABHD6 has been linked to regulation of the endocannabinoid system as it controls the accumulation of 2-arachidonoylglycerol (2-AG) at the cannabinoid receptors.

ABHD6 accounts for about 4% of 2-AG brain hydrolysis. Together, monoacylglycerol lipase (MAGL), ABHD12, and ABHD6 control 99% of 2-AG signalling in the brain.

References

ABHD6 Wikipedia


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