Species Human Entrez 94160 | Human Mouse Ensembl ENSG00000140798 | |
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Aliases ABCC12, MRP9, ATP binding cassette subfamily C member 12 External IDs MGI: 2441679 HomoloGene: 57211 GeneCards: ABCC12 | ||
Multidrug resistance-associated protein 9 is a protein that in humans is encoded by the ABCC12 gene.
Function
This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer.
References
ABCC12 Wikipedia(Text) CC BY-SA