Samiksha Jaiswal

ABCC12

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Species  Human
Entrez  94160
Human  Mouse
Ensembl  ENSG00000140798
ABCC12
Aliases  ABCC12, MRP9, ATP binding cassette subfamily C member 12
External IDs  MGI: 2441679 HomoloGene: 57211 GeneCards: ABCC12

Multidrug resistance-associated protein 9 is a protein that in humans is encoded by the ABCC12 gene.

Function

This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer.

References

ABCC12 Wikipedia


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