Samiksha Jaiswal

ABCB4

Updated on
Share on FacebookTweet on TwitterShare on LinkedIn
EC number  3.6.3.44
Human  Mouse
Species  Human
Entrez  5244
ABCB4
Aliases  ABCB4, ABC21, GBD1, ICP3, MDR2, MDR2/3, MDR3, PFIC-3, PGY3, ATP binding cassette subfamily B member 4
External IDs  OMIM: 171060 MGI: 97569 HomoloGene: 136368 GeneCards: ABCB4

Multidrug resistance protein 3 is a protein that in humans is encoded by the ABCB4 gene. ABCB4 is associated with progressive familial intrahepatic cholestasis type 3.

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate (flippase activity). The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.

References

ABCB4 Wikipedia


Similar Topics
Squareheads of the Round Table
Cristián Canío
Thomas Oppenheimer
Topics