ABH antigens secretion, i.e. presence (phenotype: secretor - Se) or absence (nonsecretor: se) of ABO blood group system antigens in saliva, milk, sweat, amniotic fluid, urine, feces and other body fluids is one of the most famous polymorphism in the field of blood antigens in body excretions. On red blood cells are in the form of a glycolipids, and in secrets it occur as glycoproteins. The first are in fat suluble, and the other in water. Previous research has shown that the allele Se is completely dominant over the allele se.
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Gene function
Secretor locus is linked to the locus of Lutheran blood antigens locus were found. Parental couples with the ability to determine the secretor status of the offsprings from this linkage potentially allows prenatal diagnosis of myotonic dystrophy (DM). Se locus and the Hh (FUT1) locus may be closely linked were also suggested.
Recessive phenotype distribution
The secretion of water-soluble A, B and H antigens in the saliva most widely was studied. A wide variation in the frequency of recessive phenotype (nonsecretor: se) was registered.
Effects
Compatibility of ABH antigens has important impacts on the prognoses of transplants of kidneys, livers and hearts, but less so on marrow, bone or cornea transplantation prognoses.