Harman Patil (Editor)

60S acidic ribosomal protein P2

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Covid-19
Species  Human
Entrez  6181
Human  Mouse
Ensembl  ENSG00000177600
60S acidic ribosomal protein P2
Aliases  RPLP2, D11S2243E, LP2, P2, RPP2, ribosomal protein lateral stalk subunit P2
External IDs  MGI: 1914436 HomoloGene: 133574 GeneCards: RPLP2

60S acidic ribosomal protein P2 is a protein that in humans is encoded by the RPLP2 gene.

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P1. The P2 protein can interact with P0 and P1 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Interactions

RPLP2 has been shown to interact with RPLP1.

References

60S acidic ribosomal protein P2 Wikipedia


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