6 pyruvoyltetrahydropterin 2' reductase

In enzymology, a 6-pyruvoyltetrahydropterin 2'-reductase (EC 1.1.1.220) is an enzyme that catalyzes the chemical reaction

6-lactoyl-5,6,7,8-tetrahydropterin + NADP⁺ ⇌ 6-pyruvoyltetrahydropterin + NADPH + H⁺

Thus, the two substrates of this enzyme are 6-lactoyl-5,6,7,8-tetrahydropterin and NADP⁺, whereas its 3 products are 6-pyruvoyltetrahydropterin, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 6-lactoyl-5,6,7,8-tetrahydropterin:NADP⁺ 2'-oxidoreductase. Other names in common use include 6-pyruvoyltetrahydropterin reductase, 6PPH4(2'-oxo) reductase, 6-pyruvoyl tetrahydropterin (2'-oxo)reductase, 6-pyruvoyl-tetrahydropterin 2'-reductase, and pyruvoyl-tetrahydropterin reductase. This enzyme participates in folate biosynthesis.