6 hydroxynicotinate dehydrogenase

In enzymology, a 6-hydroxynicotinate dehydrogenase (EC 1.17.3.3) is an enzyme that catalyzes the chemical reaction

6-hydroxynicotinate + H₂O + O₂ ⇌ 2,6-dihydroxynicotinate + H₂O₂

The 3 substrates of this enzyme are 6-hydroxynicotinate, H₂O, and O₂, whereas its two products are 2,6-dihydroxynicotinate and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH₂ groups with oxygen as acceptor. The systematic name of this enzyme class is 6-hydroxynicotinate:O2 oxidoreductase. Other names in common use include 6-hydroxynicotinic acid hydroxylase, 6-hydroxynicotinic acid dehydrogenase, and 6-hydroxynicotinate hydroxylase.