6 hydroxyhexanoate dehydrogenase

In enzymology, a 6-hydroxyhexanoate dehydrogenase (EC 1.1.1.258) is an enzyme that catalyzes the chemical reaction

6-hydroxyhexanoate + NAD⁺ ⇌ 6-oxohexanoate + NADH + H⁺

Thus, the two substrates of this enzyme are 6-hydroxyhexanoate and NAD⁺, whereas its 3 products are 6-oxohexanoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 6-hydroxyhexanoate:NAD⁺ oxidoreductase. This enzyme participates in caprolactam degradation.