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6 carboxytetrahydropterin synthase

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Covid-19
EC number  4.1.2.50
BRENDA  BRENDA entry
KEGG  KEGG entry
IntEnz  IntEnz view
ExPASy  NiceZyme view
MetaCyc  metabolic pathway
6-carboxytetrahydropterin synthase

6-carboxytetrahydropterin synthase (EC 4.1.2.50, CPH4 synthase, queD (gene), ToyB , ykvK (gene)) is an enzyme with systematic name 7,8-dihydroneopterin 3'-triphosphate acetaldehyde-lyase (6-carboxy-5,6,7,8-tetrahydropterin and triphosphate-forming). This enzyme catalyses the following ((chemical reaction))

7,8-dihydroneopterin 3'-triphosphate + H2O 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate

This enzyme binds Zn2+. It is isolated from the bacteria Bacillus subtilis and Escherichia coli. The reaction is part of the biosynthesis pathway of queuosine. The enzyme from Escherichia coli can also convert 6-pyruvoyl-5,6,7,8-tetrahydropterin and sepiapterin to 6-carboxy-5,6,7,8-tetrahydropterin.

References

6-carboxytetrahydropterin synthase Wikipedia


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