CAS Number 1210-56-6 ChemSpider 64188 Formula C13H16N2O Molar mass 216.278 g/mol | PubChem CID 71028 ChEMBL CHEMBL221811 3D model (Jmol) Interactive image | |
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6-MeO-THH, or 6-methoxy-1,2,3,4-tetrahydroharman, is a β-carboline (or more specifically a pinoline) derivative and a structural isomer of tetrahydroharmine (7-MeO-THH). 6-MeO-THH is mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved), stating that 6-MeO-THH is very similar to the other carbolines. Limited testing suggests that it possesses mild psychoactive effects at 1.5 mg/kg and is said to be about one-third as potent as 6-methoxyharmalan. It has been isolated from certain plants of the Virola family.
Pharmacology
Very little is known about the psychoactivity of 6-MeO-THH in humans. Studies in rats have shown it to bind to a number of serotonin (5-HT1 receptors and 5-HT2 receptors), dopamine (D2), benzodiazepine and imidazoline receptors.