Harman Patil (Editor)

6 (2 Aminopropyl)indole

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Routes of administration  Oral
PubChem CID  30999
Formula  C11H14N2
CAS Number  22196-72-1
ChemSpider  28759
Legal status  Uncontrolled (but covered under the Federal Analogue Act in the United States and Australia and likely under similar bills in other countries)

6-(2-Aminopropyl)indole (6-API, 6-IT) is an indole derivative with no history of use in humans. The analogue 5-API is known to be psychoactive, indicating 6-API may also be psychoactive by the same structure-activity relationship that links 5-APB and 6-APB.

Alexander Shulgin says in his book TiHKAL "From the normal 3-position to the 2, the 4, the 5, the 6 or the 7-positions. All five alpha-methyltryptamine isomers are known, but only one is known to be active in man as a CNS active material. This is the 5-isomer, 5-(2-aminopropyl)indole or 5-IT"[1].

Studies in dogs have also shown the drug to increase hemoglobin levels in the bloodstream.


  • 6-API is a positional isomer of ╬▒MT, and as such may be covered by the analogue act in the USA (depending on the nature of its psychoactive effect).
  • 6-API / 6-IT is illegal in the UK, as it was banned as a temporary class drug in June 2013, along with 9 other related compounds. On March 5, 2014 the UK Home Office announced that 6-API would be made a class B drug on 10 June 2014 alongside every other benzofuran entactogen and many structurally related drugs.
  • 6-API is covered by the Australian analogue act as an analogue of MDA "by the replacement of up to 2 carbocyclic or heterocyclic ring structures with different carbocyclic or heterocyclic ring structures"
  • References

    6-(2-Aminopropyl)indole Wikipedia

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