Harman Patil (Editor)

5 MeO NBpBrT

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Covid-19
CAS Number  155639-13-7
ChemSpider  4299315
Formula  C18H19BrN2O
Molar mass  359.26 g/mol
PubChem CID  5124753
ChEMBL  CHEMBL57427
3D model (Jmol)  Interactive image
5-MeO-NBpBrT httpsuploadwikimediaorgwikipediacommonsthu

5-MeO-NBpBrT (5-Methoxy-N-(4-bromobenzyl)tryptamine) is a N-substituted member of the methoxytryptamine family of compounds. Like other such compounds it acts as an antagonist for the 5-HT2A receptor, with a claimed 100x selectivity over the closely related 5-HT2C receptor. While N-benzyl substitution of psychedelic phenethylamines often results in potent 5-HT2A agonists, it had been thought that N-benzyl tryptamines show much lower efficacy and are either very weak partial agonists or antagonists at 5-HT2A, though more recent research has shown stronger agonist activity for 3-substituted benzyl derivatives. Extending the benzyl group to a substituted phenethyl can also recover agonist activity in certain cases.

References

5-MeO-NBpBrT Wikipedia


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