4 hydroxymuconic semialdehyde dehydrogenase

In enzymology, a 4-hydroxymuconic-semialdehyde dehydrogenase (EC 1.2.1.61) is an enzyme that catalyzes the chemical reaction

The 3 substrates of this enzyme are 4-hydroxymuconic semialdehyde, NAD⁺, and H₂O, whereas its 3 products are maleylacetate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase. This enzyme participates in gamma-hexachlorocyclohexane degradation.