Supriya Ghosh (Editor)

4 hydroxy tetrahydrodipicolinate reductase

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EC number
  
1.17.1.8

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
9055-46-3

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, a 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) is an enzyme that catalyzes the chemical reaction

(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O ⇌ (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+

The 3 substrates of this enzyme are (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate, NAD+ or NADP+, and H2O, whereas its 3 products are (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate, NADH or NADPH, and H+.

This enzyme participates in lysine biosynthesis.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 groups with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate:NAD(P)+ 4-oxidoreductase. Other names in common use include:

  • dihydrodipicolinate reductase,
  • dihydrodipicolinic acid reductase, and
  • 2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase.

    • References

    4-hydroxy-tetrahydrodipicolinate reductase Wikipedia
    (Text) CC BY-SA