EC number 6.2.1.33 ExPASy NiceZyme view | CAS number 141583-20-2 | |
In enzymology, a 4-chlorobenzoate—CoA ligase (EC 6.2.1.33) is an enzyme that catalyzes the chemical reaction
4-chlorobenzoate + CoA + ATP
The 3 substrates of this enzyme are 4-chlorobenzoate, CoA, and ATP, whereas its 3 products are 4-chlorobenzoyl-CoA, AMP, and diphosphate.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is 4-chlorobenzoate:CoA ligase. This enzyme participates in 2,4-dichlorobenzoate degradation. It employs one cofactor, magnesium.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T5D and 1T5H.
References
4-chlorobenzoate—CoA ligase Wikipedia(Text) CC BY-SA