EC number 4.1.1.44 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 37289-46-6 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a 4-carboxymuconolactone decarboxylase (EC 4.1.1.44) is an enzyme that catalyzes the chemical reaction
2-carboxy-2,5-dihydro-5-oxofuran-2-acetateHence, this enzyme has one substrate, 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate, and two products, 4,5-dihydro-5-oxofuran-2-acetate and CO2.
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate carboxy-lyase (4,5-dihydro-5-oxofuran-2-acetate-forming). Other names in common use include gamma-4-carboxymuconolactone decarboxylase, and 4-carboxymuconolactone carboxy-lyase. This enzyme participates in benzoate degradation via hydroxylation.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2AF7.