4 Hydroxycoumarin synthase

4-hydroxycoumarin synthase (EC 2.3.1.208, BIS2, BIS3) is an enzyme with systematic name malonyl-CoA:2-hydroxybenzoyl-CoA malonyltransferase. This enzyme catalyses the following chemical reaction

malonyl-CoA + 2-hydroxybenzoyl-CoA ⇌ 2 CoA + 4-hydroxycoumarin + CO₂

This polyketide synthase can also accept benzoyl-CoA as substrate.