Neha Patil (Editor)

4' Dimethylamino 7,8 dihydroxyflavone

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Covid-19
ATC code  None
PubChem CID  44610701
ChEMBL  CHEMBL1800922
Molar mass  297.3053 g/mol
CAS Number  1205548-04-4
ChemSpider  26630138
Formula  C17H15NO4
4'-Dimethylamino-7,8-dihydroxyflavone httpsuploadwikimediaorgwikipediacommonsthu

4'-Dimethylamino-7,8-dihydroxyflavone (4'-DMA-7,8-DHF) is a synthetic flavone and selective small-molecule agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF), that was derived from structural modification of 7,8-dihydroxyflavone (7,8-DHF). Relative to 7,8-DHF, 4'-DMA-7,8-DHF possesses higher agonistic activity at TrkB, is significantly more potent than 7,8-DHF both in vitro and in vivo, and has a longer duration of action (peaking at 4 hours and "partially decaying" at 8~16 hours in rodents). The compound has been found to produce neuroprotective, neurogenic, and antidepressant-like effects in animals.

References

4'-Dimethylamino-7,8-dihydroxyflavone Wikipedia


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