3beta hydroxy 5beta steroid dehydrogenase

In enzymology, a 3beta-hydroxy-5beta-steroid dehydrogenase (EC 1.1.1.277) is an enzyme that catalyzes the chemical reaction

3beta-hydroxy-5beta-pregnane-20-one + NADP⁺ ⇌ 5beta-pregnan-3,20-dione + NADPH + H⁺

Thus, the two substrates of this enzyme are 3beta-hydroxy-5beta-pregnane-20-one and NADP⁺, whereas its 3 products are 5beta-pregnan-3,20-dione, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 3beta-hydroxy-5beta-steroid:NADP⁺ 3-oxidoreductase. Other names in common use include 3beta-hydroxysteroid 5beta-oxidoreductase, and 3beta-hydroxysteroid 5beta-progesterone oxidoreductase.