3alpha hydroxy 5beta androstane 17 one 3alpha dehydrogenase

In enzymology, a 3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase (EC 1.1.1.152) is an enzyme that catalyzes the chemical reaction

3alpha-hydroxy-5beta-androstane-17-one + NAD⁺ ⇌ 5beta-androstane-3,17-dione + NADH + H⁺

Thus, the two substrates of this enzyme are 3alpha-hydroxy-5beta-androstane-17-one and NAD⁺, whereas its 3 products are 5beta-androstane-3,17-dione, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 3alpha-hydroxy-5beta-steroid:NAD⁺ 3-oxidoreductase. Other names in common use include etiocholanolone 3alpha-dehydrogenase, etiocholanolone 3alpha-dehydrogenase, and 3alpha-hydroxy-5beta-steroid dehydrogenase. This enzyme participates in androgen and estrogen metabolism.