Girish Mahajan (Editor)

3alpha,7alpha,12alpha trihydroxycholestan 26 al 26 oxidoreductase

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
EC number
  
1.2.1.40

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
62213-58-5

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, a 3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase is an enzyme that catalyzes the chemical reaction:

(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + NAD+ + H2O ⇌ (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + NADH + 2 H+

The 3 substrates of this enzyme are (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al, NAD+, and H2O, whereas its 2 products are (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate, NADH, and H+. This enzyme participates in bile acid biosynthesis.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+ 26-oxidoreductase. Other names in common use include:

  • cholestanetriol-26-al 26-dehydrogenase,
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al, dehydrogenase,
  • trihydroxydeoxycoprostanal dehydrogenase,
  • THAL-NAD oxidoreductase,
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+, and
  • 26-oxidoreductase.

    • References

    3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase Wikipedia
    (Text) CC BY-SA


    Similar Topics