3 hydroxypropionate dehydrogenase (NADP )

3-hydroxypropionate dehydrogenase (NADP⁺) (EC 1.1.1.298) is an enzyme with systematic name 3-hydroxypropionate:NADP⁺ oxidoreductase. This enzyme catalyses the following chemical reaction

This enzyme catalyses the reduction of malonate semialdehyde to 3-hydroxypropionate, which is a key step in the 3-hydroxypropionate and the 3-hydroxypropionate/4-hydroxybutyrate cycles, autotrophic CO₂ fixation pathways found in some green non-sulfur phototrophic bacteria and archaea, respectively. The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyses the upstream reaction in the pathway, EC 1.2.1.75. Different from EC 1.1.1.59, 3-hydroxypropionate dehydrogenase (NAD⁺), by cofactor preference.