Harman Patil

3 hydroxybutyryl CoA dehydrogenase

Updated on
Share on FacebookTweet on TwitterShare on LinkedIn
EC number  1.1.1.157
IntEnz  IntEnz view
ExPASy  NiceZyme view
CAS number  39319-78-3
BRENDA  BRENDA entry
KEGG  KEGG entry
3-hydroxybutyryl-CoA dehydrogenase

In enzymology, a 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157) is an enzyme that catalyzes the chemical reaction

(S)-3-hydroxybutanoyl-CoA + NADP+ 3-acetoacetyl-CoA + NADPH + H+

Thus, the two substrates of this enzyme are (S)-3-hydroxybutanoyl-CoA and NADP+, whereas its 3 products are 3-acetoacetyl-CoA, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase. Other names in common use include beta-hydroxybutyryl coenzyme A dehydrogenase, L(+)-3-hydroxybutyryl-CoA dehydrogenase, BHBD, dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine, dinucleotide phosphate), L-(+)-3-hydroxybutyryl-CoA dehydrogenase, and beta-hydroxybutyryl-CoA dehydrogenase. This enzyme participates in benzoate degradation via coa ligation and butanoate metabolism.

References

3-hydroxybutyryl-CoA dehydrogenase Wikipedia


Similar Topics
H Jefferson Powell
Gaili Schoen
Lou Esa
Topics