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3 deoxy manno octulosonate cytidylyltransferase

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EC number
  
2.7.7.38

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
37278-28-7

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, a 3-deoxy-manno-octulosonate cytidylyltransferase (EC 2.7.7.38) is an enzyme that catalyzes the chemical reaction

CTP + 3-deoxy-D-manno-octulosonate diphosphate + CMP-3-deoxy-D-manno-octulosonate

Thus, the two substrates of this enzyme are CTP and 3-deoxy-D-manno-octulosonate, whereas its two products are diphosphate and CMP-3-deoxy-D-manno-octulosonate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase. Other names in common use include CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase, 2-keto-3-deoxyoctonate cytidylyltransferase, 3-Deoxy-D-manno-octulosonate cytidylyltransferase, CMP-3-deoxy-D-manno-octulosonate synthetase, CMP-KDO synthetase, CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase, and cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase. This enzyme participates in lipopolysaccharide biosynthesis.

Structural studies

As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes 1GQ9, 1GQC, 1H6J, 1H7E, 1H7F, 1H7G, 1H7H, 1H7T, 1VH1, 1VH3, and 1VIC.

References

3-deoxy-manno-octulosonate cytidylyltransferase Wikipedia