EC number 2.7.7.38 ExPASy NiceZyme view | CAS number 37278-28-7 | |
In enzymology, a 3-deoxy-manno-octulosonate cytidylyltransferase (EC 2.7.7.38) is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are CTP and 3-deoxy-D-manno-octulosonate, whereas its two products are diphosphate and CMP-3-deoxy-D-manno-octulosonate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase. Other names in common use include CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase, 2-keto-3-deoxyoctonate cytidylyltransferase, 3-Deoxy-D-manno-octulosonate cytidylyltransferase, CMP-3-deoxy-D-manno-octulosonate synthetase, CMP-KDO synthetase, CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase, and cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase. This enzyme participates in lipopolysaccharide biosynthesis.
Structural studies
As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes 1GQ9, 1GQC, 1H6J, 1H7E, 1H7F, 1H7G, 1H7H, 1H7T, 1VH1, 1VH3, and 1VIC.