Supriya Ghosh (Editor)

3 Ketosteroid reductase

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EC number
  
1.1.1.270

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
42616-29-5

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, a 3-keto-steroid reductase (EC 1.1.1.270) is an enzyme that catalyzes the chemical reaction

4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP+ 4alpha-methyl-5alpha-cholest-7-en-3-one + NADPH + H+

Thus, the two substrates of this enzyme are 4alpha-methyl-5alpha-cholest-7-en-3beta-ol and NADP+, whereas its 3 products are 4alpha-methyl-5alpha-cholest-7-en-3-one, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3beta-hydroxy-steroid:NADP+ 3-oxidoreductase. This enzyme is also called 3-KSR. This enzyme participates in biosynthesis of steroids.

References

3-Ketosteroid reductase Wikipedia