3,5,7 Trioxododecanoyl CoA synthase

3,5,7-Trioxododecanoyl-CoA synthase (EC 2.3.1.206, TKS) is an enzyme with systematic name malonyl-CoA:hexanoyl-CoA malonyltransferase (3,5,7-trioxododecanoyl-CoA-forming). This enzyme catalyses the following chemical reaction

3 malonyl-CoA + hexanoyl-CoA ⇌ 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO₂

This polyketide synthase catalyse the first step in the cannabinoids biosynthetic pathway of the plant Cannabis sativa.