27S pre rRNA (guanosine2922 2' O) methyltransferase

27S pre-rRNA (guanosine²⁹²²-2'-O)-methyltransferase (EC 2.1.1.167, Spb1p (gene), YCL054W (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:27S pre-rRNA (guanosine²⁹²²-2'-O-)-methyltransferase. This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanosine²⁹²² in 27S pre-rRNA ⇌ S-adenosyl-L-homocysteine + 2'-O-methylguanosine²⁹²² in 27S pre-rRNA

Spb1p is a site-specific 2'-O-ribose RNA methyltransferase that catalyses the formation of 2'-O-methylguanosine2922.