Rahul Sharma (Editor)

25 hydroxycholesterol 7α hydroxylase

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EC number
  
1.14.13.100

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

MetaCyc
  
metabolic pathway

25-hydroxycholesterol 7alpha-hydroxylase (EC 1.14.13.100, 25-hydroxycholesterol 7alpha-monooxygenase, CYP7B1, CYP7B1 oxysterol 7alpha-hydroxylase) is an enzyme with systematic name cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating). This enzyme catalyses the following chemical reaction

(1) cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 ⇌ cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O (2) cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 ⇌ cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O

25-hydroxycholesterol 7α-hydroxylase is a heme-thiolate protein (P-450).

References

25-hydroxycholesterol 7α-hydroxylase Wikipedia
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