EC number 1.14.13.13 Human Mouse | Species Human Entrez 1594 | |
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Aliases CYP27B1, CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR, cytochrome P450 family 27 subfamily B member 1 External IDs OMIM: 609506 MGI: 1098274 HomoloGene: 37139 GeneCards: CYP27B1 | ||
25-Hydroxyvitamin D3 1-alpha-hydroxylase (VD3 1A hydroxylase) also known as cytochrome p450 27B1 (CYP27B1) or simply 1-alpha-hydroxylase is a cytochrome P450 enzyme that in humans is encoded by the CYP27B1 gene.
VD3 1A hydroxylase is located in the proximal tubule of the kidney and a variety of other tissues, including skin (keratinocytes), immune cells, and bone (osteoblasts). The enzyme catalyzes the hydroxylation of Calcifediol to calcitriol (the bioactive form of Vitamin D):
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.
References
25-Hydroxyvitamin D3 1-alpha-hydroxylase Wikipedia(Text) CC BY-SA