23S rRNA (uridine2552 2' O) methyltransferase

23S rRNA (uridine²⁵⁵2-2'-O)-methyltransferase (EC 2.1.1.166, Um(2552) 23S ribosomal RNA methyltransferase, heat shock protein RrmJ, RrmJ, FTSJ, Um²⁵⁵² methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (uridine²⁵⁵²-2'-O-)-methyltransferase. This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + uridine²⁵⁵² in 23S rRNA ⇌ S-adenosyl-L-homocysteine + 2'-O-methyluridine²⁵⁵² in 23S rRNA

The enzyme catalyses the 2'-O-methylation of the universally conserved U²⁵⁵² in the A loop of 23S rRNA.