23S rRNA (uracil747 C5) methyltransferase

23S rRNA (uracil⁷⁴⁷-C⁵)-methyltransferase (EC 2.1.1.189, YbjF, RumB, RNA uridine methyltransferase B) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (uracil⁷⁴⁷-C⁵)-methyltransferase. This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + uracil⁷⁴⁷ in 23S rRNA ⇌ S-adenosyl-L-homocysteine + 5-methyluracil⁷⁴⁷ in 23S rRNA

The enzyme specifically methylates uracil⁷⁴⁷ at C⁵ in 23S rRNA.