23S rRNA (uracil1939 C5) methyltransferase

23S rRNA (uracil¹⁹³⁹-C⁵)-methyltransferase (EC 2.1.1.190, RumA, RNA uridine methyltransferase A, YgcA) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (uracil¹⁹³⁹-C⁵)-methyltransferase. This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + uracil¹⁹³⁹ in 23S rRNA ⇌ S-adenosyl-L-homocysteine + 5-methyluracil¹⁹³⁹ in 23S rRNA

The enzyme specifically methylates uracil¹⁹³⁹ at C⁵ in 23S rRNA.