23S rRNA (adenine2503 C2,C8) dimethyltransferase

23S rRNA (adenine²⁵⁰³-C²,C⁸)-dimethyltransferase (EC 2.1.1.194, Cfr, Cfr methyltransferase, Cfr rRNA methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (adenine²⁵⁰³-C²,C⁸)-dimethyltransferase. This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + adenine²⁵⁰³ in 23S rRNA ⇌ 2 S-adenosyl-L-homocysteine + 2,8-dimethyladenine²⁵⁰³ in 23S rRNA

This enzyme contains an [4Fe-S] cluster.