2016 US Open – Women's Doubles

Martina Hingis and Sania Mirza were the defending champions, but chose not to participate together. Mirza teamed up with Barbora Strýcová, but lost in the quarterfinals to Caroline Garcia and Kristina Mladenovic. Hingis played alongside Coco Vandeweghe, but lost in the semifinals to Garcia and Mladenovic.

Bethanie Mattek-Sands and Lucie Šafářová won the title, defeating Garcia and Mladenovic in the final, 2–6, 7–6^(7–5), 6–4. It was their third Grand Slam title together.