| 6–4, 6–2|
| 64 (6WC)|
| Sara Errani
2012 US Open – Women's Doubles Wikipedia
Liezel Huber and Lisa Raymond were the defending champions but lost to Hsieh Su-wei and Anabel Medina Garrigues in the third round.
Kim Clijsters played her last ever women's doubles match before retiring at these championships. Playing with Kirsten Flipkens, she lost to Zhang Shuai and Chuang Chia-jung in the first round.
Sara Errani and Roberta Vinci defeated Andrea Hlaváčková and Lucie Hradecká 6–4, 6–2 in the final to win the title.