|Champion Andy Murray|
|Runner-up Novak Djokovic|
|Final score 7–6, 7–5, 2–6, 3–6, 6–2|
Novak Djokovic was the defending champion, but he was defeated in the final by Andy Murray 7–6(12–10), 7–5, 2–6, 3–6, 6–2 in 4 hours 54 minutes, equalling the record for the longest US Open final in history. By defeating Djokovic, Murray claimed his first Grand Slam title, becoming the first British man since Fred Perry, winner of the US Open in 1936, to win a Grand Slam championship, after having been runner-up on four previous occasions.
Andy Roddick, the 2003 champion, played his last professional match here before retirement, losing to Juan Martín del Potro in the fourth round and bringing a close to his 13-year career.
The 2012 tournament marked the first time since the 2004 French Open that neither Roger Federer nor Rafael Nadal reached the semifinals of a Grand Slam event.