| Bob Bryan
| 6–1, 4–6, [12–10]|
| Marcel Granollers
Michaël Llodra and Nenad Zimonjić were the defending champions, but Llodra chose not to compete this year.
Zimonjić played alongside Paul Hanley, but the lost to Bob and Mike Bryan in the quarterfinals, who won the tournament in the end against Marcel Granollers and Marc López 6–1, 4–6, [12–10].
2012 Rogers Cup – Men's Doubles Wikipedia
All seeds receive a bye into the second round.