| 7–6(4), 7–6(8)|
| Victoria Azarenka
Cara Black and Liezel Huber were the defending champions. Both were present that year, but chose to compete with different players.
Black partnered with Anastasia Rodionova but lost 6–4, 6–4 in quarterfinals against Gisela Dulko and Flavia Pennetta. Huber partnered with Nadia Petrova but lost 7–5, 6–2 in semifinals against Lisa Raymond and Rennae Stubbs.
Victoria Azarenka and Maria Kirilenko won 7–6(4),7–6(8) in the final against Lisa Raymond and Rennae Stubbs.
2010 Western & Southern Financial Group Women's Open – Doubles Wikipedia
The top four seeds receive a bye into the second round.