2010 French Open – Women's Singles

Svetlana Kuznetsova was the defending champion, but lost in the third round to Maria Kirilenko.

Francesca Schiavone claimed her maiden Grand Slam title, defeated Samantha Stosur 6–4, 7–6^(7–2) in the final, also playing in her first Major singles final. Schiavone became the first Italian woman to win a Grand Slam tournament. This was the first time since the 2004 tournament that all were maiden finalists.

This tournament is notable for the final appearance of former world No. 1 Justine Henin in the main draw following her comeback. Prior to her defeat to Stosur in the fourth round, Henin had a streak of 24 match wins in the tournament.