| Francesca Schiavone|
| Samantha Stosur|
2010 French Open – Women's Singles Wikipedia
Svetlana Kuznetsova was the defending champion, but lost in the third round to Maria Kirilenko.
Francesca Schiavone claimed her maiden Grand Slam title, defeated Samantha Stosur 6–4, 7–6(7–2) in the final, also playing in her first Major singles final. Schiavone became the first Italian woman to win a Grand Slam tournament. This was the first time since the 2004 tournament that all were maiden finalists.
This tournament is notable for the final appearance of former world No. 1 Justine Henin in the main draw following her comeback. Prior to her defeat to Stosur in the fourth round, Henin had a streak of 24 match wins in the tournament.