| Bob Bryan
| 6–4, 6–7, [10–7]|
| Fabrice Santoro
Mark Knowles and Daniel Nestor were the defending champions, but lost in semifinals to Bob Bryan and Mike Bryan.
Fabrice Santoro and Nenad Zimonjić won the title, defeating Bob Bryan and Mike Bryan 6–4, 6–7(4–7), [10–7] in the final.
2007 Internazionali BNL d'Italia – Men's Doubles Wikipedia
All seeds received a bye into the second round.