2006 US Open – Mixed Doubles

The United States Open Tennis Championships is a hardcourt tennis tournament held annually at Flushing Meadows, starting on the last Monday in August and lasting for two weeks. The tournament consists of five main championship events: men's and women's singles, men's and women's doubles, and mixed doubles, with additional tournaments for seniors, juniors, and wheelchair players.

In 2006, the mixed doubles event was won by Bob Bryan and Martina Navratilova, both of the United States, who beat Martin Damm and Květa Peschke, both of the Czech Republic, 6-2, 6-3 in the final.