| Fernando González|
| Andy Roddick|
Fernando González was the defending champion but lost in the first round to Michal Tabara.
Andy Roddick won in the final 7–5, 6–3 against Hyung-Taik Lee.
2001 U.S. Men's Clay Court Championships – Singles Wikipedia
A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated.