2 oxoaldehyde dehydrogenase (NADP )

In enzymology, a 2-oxoaldehyde dehydrogenase (NADP+) (EC 1.2.1.49) is an enzyme that catalyzes the chemical reaction

a 2-oxoaldehyde + NADP⁺ + H₂O ⇌ a 2-oxo acid + NADPH + H⁺

The 3 substrates of this enzyme are 2-oxoaldehyde, NADP⁺, and H₂O, whereas its 3 products are 2-oxo acid, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoaldehyde:NADP+ 2-oxidoreductase. Other names in common use include alpha-ketoaldehyde dehydrogenase, methylglyoxal dehydrogenase, NADP+-linked alpha-ketoaldehyde dehydrogenase, 2-ketoaldehyde dehydrogenase, NADP+-dependent alpha-ketoaldehyde dehydrogenase, and 2-oxoaldehyde dehydrogenase (NADP+). This enzyme participates in pyruvate metabolism.