2 hydroxy 6 oxo 6 phenylhexa 2,4 dienoate reductase

In enzymology, a 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase (EC 1.3.1.40) is an enzyme that catalyzes the chemical reaction

2,6-dioxo-6-phenylhexanoate + NADP⁺ ⇌ 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + NADPH + H⁺

Thus, the two substrates of this enzyme are 2,6-dioxo-6-phenylhexanoate and NADP⁺, whereas its 3 products are 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2,6-dioxo-6-phenylhexanoate:NADP+ Delta2-oxidoreductase. Other names in common use include 2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide, and adenine dinucleotide phosphate) reductase.