In enzymology, a 2-alkenal reductase (EC 188.8.131.52) is an enzyme that catalyzes the chemical reaction
n-alkanal + NAD(P)+
alk-2-enal + NAD(P)H + H+
The 3 substrates of this enzyme are n-alkanal, NAD+, and NADP+, whereas its 4 products are alk-2-enal, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is n-alkanal:NAD(P)+ 2-oxidoreductase. Other names in common use include NAD(P)H-dependent alkenal/one oxidoreductase, and NADPH:2-alkenal alpha,beta-hydrogenase.
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2DM6, 2J3J, and 2J3K.