2 (S) hydroxypropyl CoM dehydrogenase

In enzymology, a 2-(S)-hydroxypropyl-CoM dehydrogenase (EC 1.1.1.269) is an enzyme that catalyzes the chemical reaction

2-(S)-hydroxypropyl-CoM + NAD⁺ ⇌ 2-oxopropyl-CoM + NADH + H⁺

Thus, the two substrates of this enzyme are 2-(S)-hydroxypropyl-CoM and NAD⁺, whereas its 3 products are 2-oxopropyl-CoM, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 2-[2-(S)-hydroxypropylthio]ethanesulfonate:NAD⁺ oxidoreductase. This enzyme is also called 2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase.